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A review of the latest evidence on the risk of thromboembolism in association with combined hormonal contraceptives ( CHCs ) has concluded that: a) the risk of blood clots with all low-dose CHCs is sm ...


There is an increased risk of tuberculosis, or reactivation of latent tuberculosis, during treatment with tumour necrosis factor alpha ( TNF-alpha ) inhibitors. Tuberculosis in patients receivin ...


Voriconazole ( Vfend ) is known to be associated with a risk of liver toxicity, phototoxicity, and squamous cell carcinoma of the skin. Liver function before starting treatment with Voriconazole sho ...


Domperidone ( Motilium ) is associated with a small increased risk of serious cardiac side effects. Its use is now restricted to the relief of nausea and vomiting and the dosage and duration of use ha ...


Statins ( HMG-CoA reductase inhibitors ) are widely used medicines for patients with lipid disorders and in the primary and secondary prevention of myocardial infarction and stroke. The statins curren ...


New data on serious hypersensitivity reactions following Ferumoxytol administration are currently being reviewed by the European Medicines Agency ( EMA ). MHRA ( Medicines and Healthcare Products Re ...


An association between Testosterone therapy and cardiovascular disease has been reported and Testosterone therapy use is increasing rapidly. Researchers have conducted a cohort study of the risk of ...



Bloodstream infections are an important cause of morbidity and mortality in neonatal intensive care units. Before and during neonatal catheterisation, skin disinfection and aseptic technique are cruci ...


Despite a range of actions taken in 2013 to ensure the safe use of seasonal influenza vaccines in children, there were still 43 confirmed cases of bioCSL Fluvax being administered to children under 5 ...


Health professionals are advised that the Product Information for Quetiapine has been updated to include additional information regarding risks of QT prolongation. Postmarketing reports of QT prolong ...


Immunotherapies stimulate the immune system with the goal of eradicating tumors, and some side effects are likely related to this immunologic mechanism of action. Inhibiting the CTLA-4 and PD-1 pathwa ...


Health professionals are reminded of the risks associated with extended or repeated occupational exposure to Methoxyflurane. Methoxyflurane is an anaesthetic that is only approved for short-term us ...


Ivabradine ( Procorolan ) is used to treat symptoms of long-term stable angina in adults with coronary heart disease who have a normal heart rhythm. Ivabradine is also used in patients with long-term ...


Health professionals are advised of the risk of rare but very serious adverse events when using Codeine to treat children after tonsillectomy and/or adenoidectomy. Codeine is a widely used opioid a ...